Longevity with naturals is possible but needs to be worked on. I have made a couple of bases which really help. Naturals with good longevity include vanilla, sandalwood, oakmoss, patchouli, oud, labdanum. I make concentrated mixtures of theses and other ingredients and then add them to perfumes in varying quantities. Ambergris is great for longevity if you can obtain it.
Also getting concentrations right is important. You may need to use quite high concentrations of oakmoss and sandalwood and vanilla but these last ages if you do.
A simple mixture of herbal/citrus/rose/sandalwood can develop beautifully and last for many hours if put together correctly.
The problem with naturals is my opinion, is not longevity but sillage. After a short time of intensive sillage, they tend to drop down to very quiet radiance.
Re tobacco - this is a very powerrful note and hard to blend. I had great trouble using it and spent months before I figured out a few good uses. A little goes a very long way.
Bigsly - tobacco is an absolute (thick, sticky and heavy) and thus needs diluting in alcohol (I suggest at 10%) before use.