Ah, Andrews! I keep forgetting about them (they're a high end women's clothing store, so it's not like I otherwise would go in there).
I believe they have Amouage and a few bonds, maybe some Serge too?
Pir - an odd mix of frags, terribly laid out and incomplete sets. Mark Buxton, some Etro, some old random L'Artisan, some random MPG's.
Noor - Everything from Santa Maria Novella, to L'Artisan, Comme Des Garcons, L'eau Italie, Delrae, Dyptique (and candles), and launching soon - Heeley (I think).
Holt's - all the mainstream designer stuff, plus Tom Ford, Bond #9, MALLE!!! (new), across the way is the Chanel area (tres cool), Kilian, Lalique, etc... Don't forget to check downstairs for the men's stuff. There are some random goodies like Boise 1920, Art of Shaving (if you're into that sort of thing), and more.
Harry's - mostly mainstream stuff, but they do have the Tom Ford line and are quite generous. Check for Adam, a tall handsome nice guy. On the second floor they store the flacons incase you want 4ml samples.
Along bloor - Guerlain is worth checking out. Chanel, well holt's has the exclusive line anyway. Hermes is always nice. There's a Winners in the big building there and they have some random frags on teh second floor.