I've recently been trying to decide on which bottle to get (either Vetiver 46 or CdG 2MAN). In the end I bought a bottle of Vetiver 46, but here are my observations contrasting the two fragrances.
Both have that amazing candle-wax, smoke accord and saffron in the opening - that's what makes them so similar to each other. Once you get into the heart, they start to differ though. CdG 2MAN is more aromatic, with the addition of spices like nutmeg, and leather. I also get some sort of rosemary note in 2MAN. At this point in the drydown, Vetiver 46, on the other hand, continues to smolder and remain smokey. In fact, it starts to go from candle wax smoke to campfire smoke. There's a big, smokey, salty vetiver note that comes out strong with the campfire smoke (gaiac wood?). In contrast, CdG 2MAN lightens up, the smoke passes, and all you're left with is an aromatic and light vetiver mixed with herbs, spice and leather.
In the base, you get some vanilla, campfire smoke and vetiver in Vetiver 46, but more of a leathery-vetiver and cedar (sans vanilla) in 2MAN.
In summary, although they contain a lot of the same notes, they differ in their progression from the candle wax accord. I only smell about 6 ingredients in each fragrance, but the aforementioned notes are the major players for me. It's crazy to think that Vetiver 46 actually has 46 ingredients!
I smell the following notes in succession for each fragrance:
CdG 2MAN: candle wax smoke, saffron, nutmeg, rosemary, vetiver, leather, cedar
Vetiver 46: candle wax smoke, saffron, campfire smoke, clove, vetiver, vanilla
Both are great fragrances, but I prefer Vetiver 46 as it lasts longer, it's smokier and somewhat more mysterious to me. They're both equally masculine, well constructed and unique, but Vetiver 46 gets my vote.