I just tested Arquiste's Anima Dulcis on Sunday, and it was too much for me. Granted, I was already feeling pretty exhausted and slightly ill, so not the best time to heavily skin test such a rich scent. I didn't scrub it though, and I'd try it again.
The first time I scrubbed a scent was when I was at the airport and tested Guerlain Habit Rouge EDT and Chanel Antaeus at the same time (one on each wrist). It was way too much, and this was at the very start of my fragrance journey. I'm glad I didn't get on a plane without scrubbing, and actually I enjoyed the faint smell of both after I scrubbed. Now I enjoy both scents and own a bottle of vintage Habit Rouge EDC.
I had to scrub SL Chypre Rouge, something in the heart was nauseating and gave me a headache. I found a very similar sickening accord in Molton Brown Rogart. Those two actually make me ill.