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Moxalone

post #1 of 7
3/6/13 at 5:06am
Thread Starter 
I wonder if anyone here knows whether Moxalone is biodegradable or not.
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post #2 of 7
3/6/13 at 10:51am
I can't find a database page for it at TGSC, where are you buying it from?
It looks like it might be a Givaudan Product...

I see that Wiki lists it a captive that's been released, but more than that I am lacking...

Thanks,
Paul Kiler
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post #3 of 7
3/6/13 at 11:46am
'In 1979, M. Klaus of F. Hoffmann-La Roche discovered by serendipity a new intense
musk odorant with some damascone-like and woody nuances. In the course of synthetic
work on aromatic retinoids he had synthesised the hexahydroindene 65, which because
of its powerful odour soon became internally known as klausenone (65) in Hoffmann-La
Roche and also at Givaudan, at that time the flavour and fragrance division of Roche. As
65 is structurally not an aromatic polycycle, the musk odour of 65 was rather surprising.
Attempts to develop an industrially feasible route to klausenone (65) turned out to be
more difficult than anticipated, and thus derivatives were also investigated [38]. The
corresponding alcohol, obtained by LAH reduction of 65, possessed as well a pronounced
musk note, indicating the carbonyl function was no prerequiste. Surprisingly, the epoxide
intermediate 66, en route to a methyl klausenone by acid-catalysed rearrangement, turned
out to be the best musk odorant of the whole series and it was introduced into perfumery
as Moxalone® (66). Moxalone® (66) had its debut in »Eden« (Cacharel, 1994) by Jean
Guichard and was even at 0.62% an important cornerstone in the unisex fragrance
»CK be« (C. Klein, 1996) created by René Morgenthaler.'

bib.convdocs.org/v38471/?download=1


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post #4 of 7
3/6/13 at 1:21pm
Oh Yes, Skelly, that's a valuable resource, I had it already but great post from all of your response...
Thanks
PS, I think I should just print it out and bind it for the Perfumarium Library...
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post #5 of 7
3/7/13 at 2:27am
Thread Starter 
Pkiler: Not buying it, but am potentially interested in it - if it is biodegradable.

Sorry, but I still wonder the same thing...maybe it is possible to deduce from the text Skelly kindly posted above whether Moxalone is biodegradable or not, but I don't have the expertise to do so. Anyone?
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post #6 of 7
3/7/13 at 12:53pm
Assuming that 66 isn't a polycycle I'd say... *guess alert* yes it is.

Maybe.

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post #7 of 7
3/8/13 at 4:15am
Thread Starter 
Quote:
Originally Posted by Skelly View Post

Assuming that 66 isn't a polycycle I'd say... *guess alert* yes it is.

Maybe.

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Thanks for the guess Skelly

Anyone else?
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