Code of Conduct
Results 1 to 2 of 2
  1. #1

    Default Speaking of study...

    ...shows it's good for you.

    WASHINGTON (Reuters) - U.S. researchers said they have identified the compound in grapefruit juice that affects how some drugs are absorbed in the body and said on Tuesday it might be used to help lower dosages for some patients.

    Grapefruit juice is known for its effects on drug metabolism and is avoided by some patients while other deliberately take their drugs with the juice.

    The reason is an intestinal enzyme called CYP3A, which partially destroys drugs as they are absorbed. Grapefruit juice, like no other fruit juice, interferes with CYP3A, so the body ends up absorbing more of the drug.

    Dr. Paul Watkins of the University of North Carolina at Chapel Hill and colleagues say they have identified the substance in grapefruit juice that is responsible -- furanocoumarin.

    "It should now be possible to market the furanocoumarin-free grapefruit juice to patients who would otherwise need to avoid grapefruit," Watkins said in a statement.

    "In addition, it should be possible to screen new foods for the potential for drug interactions by determining whether they contain furanocoumarins," Watkins said.

    "Finally, it may be possible to add furanocoumarins to formulations of certain drugs that tend to be poorly or erratically absorbed to improve their oral delivery."

    To test the theory that furanocoumarin was the responsible compound, Watkins and colleagues filtered it out grapefruit juice, which they discovered was then less bitter but otherwise unaltered.

    Then they tested 18 men and women taking various drugs on a regular basis including aspirin and birth control pills.

    Each fasted in the hospital and got a single dose of the blood pressure drug felopidine, sold under the brand name Plendil, along with either normal grapefruit juice, furanocoumarin-free juice or orange juice.

    They then ate and drank normally and blood was taken regularly all day.

    In each volunteer, the normal grapefruit juice made between 6 percent to 230 percent more Plendil available in the blood, the researchers reported in the American Journal of Clinical Nutrition. The furanocoumarin-free grapefruit juice and orange juice had no such effect, they reported.

  2. #2
    ChrisW's Avatar
    Join Date
    Mar 2006
    New Jersey

    Default Re: Speaking of study...

    Hm, interesting! I'll remember to stock up on grapefruit juice the next time I...just kidding!

Similar Threads

  1. Comprehensive list of Grapefruit scents!
    By Dane in forum Male Fragrance Discussion
    Replies: 40
    Last Post: 26th May 2011, 09:53 PM
  2. Substitutes for Difficult Notes- Grapefruit
    By Elf in forum Fragrance DIY
    Replies: 7
    Last Post: 8th March 2008, 05:49 PM
  3. best grapefruit....
    By sentir in forum Male Fragrance Discussion
    Replies: 37
    Last Post: 5th January 2008, 12:33 PM
  4. Bath & Body Works - Pink Grapefruit
    By oolong in forum No longer missing fragrances
    Replies: 0
    Last Post: 15th April 2007, 05:24 AM
  5. Any really nice grapefruit scents?
    By sanddrift in forum Female Fragrance Discussion
    Replies: 39
    Last Post: 11th November 2006, 07:48 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts

Loving perfume on the Internet since 2000