Most people would recommend applying to the pulse points. IE the neck, wrists, back of knees, etc. Some people apply to clothing. Some even to hair. It just depends on your own personal preference. I personally spray once to the chest and then once to my wrist (which I dab onto my other wrist and the back of my neck).
In terms of amount, some wear very little, some wear a lot (up to 50 sprays.. yeah.. there are a few basenoters who do this). I try to keep it conservative. One or two sprays is usually enough for most fragrances. However, some fragrances are obviously stronger than others and some weaker so you really just have to learn the characteristics of each and guage how much you should apply.
(BTW, no offense but you claimed to be a master of fragrances in another thread yet, to be honest, you do post very typical 'noob'ish topics. I'm not saying you're a noob but you should realize why many basenoters will view you as one, solely based on your initial posts)