First rule: no rubbing
I apply right out of the shower. Sometimes I put on lotion first. As long as it is unscented it should not interfere with the fragrance. The only problem with applying right after a shower is that the natural skin oils your body produces are gone. They are what mix with the fragrance to create your own, unique version of the scent when it is applied to your skin.
I do 4 sprays. Here is how I break it down:
One to the center of the chest
Two to the neck. One on each side of the base of the neck.
One on center of shirt to maximize longevity.
I hope that helps.