I believe it can make a huge difference!!
I have a splash bottle of Caron's Tabac Blond edc that seems to lose some richness if I spray it on from a small decant atomizer I thought spraying would enhance the smell but the opposite happens.
On the other hand, Jil Sander's No.4 is a gorgeous scent that is even better when sprayed.
I have Shalimar parfum both in spray and dab on bottles but I don't notice any difference there.