Play, one of their newest additions, is certainly one of their 'freshest' scents. However, one could go so far as to say that both Odeur 53 and Odeur 71 have their fresh sides, as well as Comme de Garcons 3. In these parts, the Incense Series and the Red Series are very popular. Among those lines, Avingnon, Kyoto, Sequoia and Palisander are standouts. Comme des Garcons 2 Man is also extremely popular, although not a personal favorite of mine. White is excellent.
Some of the later series are a little more out there, Synthetic offered us Tar, which is a personal favorite, along with some other more experimental scents like Soda and Garage. Rhubarb is a gorgeous fresh, green scent form the Sherbet Series. A few offering in the Sweet line are more on the Oriental side, but as the title suggests, they are often a little too sugary for many.
CdG is an amazing company and was my first true love when I became a fragrance fiend. Happy Smelling, you won't be disappointed!