I remember reading an interview with Christopher Brosius (owner of CB I Hate Perfume) and he said that so many women who he met in his shop, who talked to him about ideas for a new scent, always mentioned they wanted him to do a scent based on the smell of gasoline fumes. They remarked that when they were pumping the gas at their local gas station, the smell was always one that was unique, sharp and slightly comforting. I never forgot that story and I (of course) always think of it when I'm pumping gas in my car. I think it shows that synthetic notes are very worthy of appreciation.
I, personally, have had very strong emotional responses to synthetic notes, as well as natural ones. Both can affect me very deeply. At the Beach 1966 by CBIHP has a particular note in it, that smells like Coppertone suntan lotion, the way it used to smell when I was a kid. The first time I wore ATB, I sat there for a few minutes and let the waves of memories come over me, of being a kid at the beach in Naples with my family and older brother. This is one of the main reasons why I love and wear fragrances.
Of course, the synthetic 'style' can be a little overdone (CdG has made it into an art form, I must admit) but then...perfumers have overdone the natural 'style' also (just look at Aveda). As a fragrance enthusiast, these types of things really don't matter to me at all. What matters is the juice.