I'm following an advanced course in Organic Chemistry at the uni at the moment, and I'm a big proponent for synthetic ingredients. Long live technology. When used wisely and if the selected synthetic ingredients have the right effect, they have the great advantage of broadening the perfumer's palette.
Moreso, synthetic components can make naturally extracted ingredients smell *more natural* to the wearer than natural ingredients alone can do so. And this is a fact that most people ignore. It's all about the effect and end product.
There's a great difference between using synthetic aromachemicals and creating a synthetic smelling fragrance. Hell, you can even create synthetic smelling fragrances by using natural ingredients alone.