I have seen nearly no improvements in fragrances as a result of reformulation using sythetics. There is only 3% genetic variance between Chimps and us. Both are hominids but, the end result is substantial. Synthetics are ok of and by themselves as new additions to the fragrance world but, as substitutes? Give me natural. No matter how much you tell me sugar substitues is good for me, it does not replace good old sugar. Catch my drift? I think if sythetics were time traveled back to Monsieur Guerlain it may have just hastened the demise of good fragrance. Viva la natural!