Well the musk deer is an endangered species so banned. Castoreum and civet is synthetic these days too. The last civet farm was in Etheopia(sp), and now gone. Because of rules and regulations etc animal welfare companies would not risk having PETA stalking them.
Amouage kept insisting for ages they used only natural ingredients, but as their range included musk they were talking rubbish and admitted no real musk.
Some perfumers use real ambergris but this is so rare and expensive.