Take a gander at this thread here: http://www.basenotes.net/threads/212...-(city-centre)
Both Selfridges in Manchester and Trafford Centre stock Chanel Les Exclusifs, Dior La Collection and Tom Ford Private Blend. I've not been to Selfridges Manchester in a while, but I'm at the Trafford store very often. They've got a good ranges of Amouage, Clive Christian, Armani Prive, Jo Malone, Creed too.
Harvey Nichols is a good place for them too. Not only do they have a great selection of niche fragrances, but they have those little coffee beans so you can clear your sinuses! Very handy for bulk testing. Also, there's been very good feedback about the By Kilian counter at that store.
In terms of the city centre, you have Selfridges, Harvey Nichols and House of Fraser all within walking distance, but sadly there's not as much as London