You are making good points, that is, the current taste goes for unpleasant clean disinfectants that smell all but natural (Light blue and family) and are so sharp that they can cover any body odors. I cannot think of any natural material that gets anywhere close; bigarade and orange blossoms can occasionally hint to that, but only so far. The problem with these disinfectant notes, though, is not that they are synthetic. It's that they are sharp and unplesant. There are many fresh and clean things that smell pleasant, whether natural or synthetic. The 200+ years old recipe for eau de cologne is fully natural, extremely fresh, and extremely pleasant.
While I am a Creed hater, I agree with you that the house has seldom gone this far in the desire for sterility But that's not the reason why I dislike it. Mark Buxton and JC Ellena make clean and transparent perfumes too. But enough Creed critiques.
As for synthetics, they can do everything, clean or dirty (Secretions Magnifiques a case in point - it screams synthetic and is as putrid as it can be).