I agree kumquat, not taking this seriously. Its been a very long debated subject for years here. My notes in this thread are simply what I've read through the years. As kicked to death here, no one knows, can't really prove, and as long as you're happy with your method, who cares. The few times I've applied to the wrist, if it was a strong fragrance, I applied to one wrist the rubbed on to the other. If a weaker fragrance, I just put a spray on each one. I might start applying to the wrist just to keep it off my chest so that my nose doesn't get attacked. I've been doing the back of the neck lately and that seems to be working.