There is very clear evidence that galaxolide persists for a long time in people and the environment. There is no clear evidence it's doing any real harm in either place but personally I feel it's better not to use it. I use romandolide instead which alicyclic, biodegradable and very close in odour profile. Unfortunately it's also several times more expensive Ö
With tonalid the evidence isn't so clear though it is dropping out of fashion because of the desire to claim "free from polycyclic musk".